Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Mania or Mixed Feature Bipolar I Disorder: A Randomized Double-Blind Clinical Trial Study

Background: Acute mania causes many problems for the patient and others. Therefore, it is very important to eliminate symptoms quickly. Objectives: The present study made individual comparison of therapeutic effects sodium valproate combined with quetiapine or haloperidol as an add-on among patients bipolar I disorder experiencing episode mixed feature admitted a Psychiatric Center in Tehran. Methods: was double-blind clinical randomized trial conducted on 36 patients. All were investigated by Young Mania Rating Scale (YMRS). lasted six weeks total (after raising drug dosage maximum level). We prescribed 15 mg/kg plus 500 mg daily one group 10 other group. In addition, equivalent prescribed. This used different data analysis methods such Paired t test, ANOVA, chi-square test. Results: YMRS scores did not show any statistically significant difference between receiving groups (P > 0.05). Conclusions: paper argued that combination either could be effective management acute reduce severity duration symptoms, although there no efficacy these two pharmacological therapies.